Aging

Extending Life: Chris Mirabile Discusses Strategies to Combat Aging, Part 1
October 22, 2024
Unlocking Longevity: Deep dive into anti-aging science and Innovations In this comprehensive episode. Chris Mirabile, founder and CEO of NOVOS, the first-ever company to develop science-based solutions to slow down aging and increase human lifespan, reveals breakthroughs in longevity and health span extension. Chris recounts his personal health journey, starting with a brain tumor at age 16, that led to his passion for anti-aging science. The discussion covers various mechanisms of aging, including mitochondrial dysfunction, cellular senescence, and telomere shortening, as well as innovative interventions like rapamycin, stem cells, and lifestyle modifications. They also explore Novos' science-driven formulations, their AI-powered facial analysis tool, and practical strategies for optimizing health and longevity, such as sleep, stress management, and diet. Notable topics include the importance of early disease detection, the benefits of ingredients like lithium, Pterostilbene, NMN, and the impact of personalized health recommendations via the NOVOS Life app. Click HERE for part 2.

Extending Life: Chris Mirabile Discusses Strategies to Combat Aging, Part 2

Dr. Hoffman continues his conversation with Chris Mirabile, Founder, CEO at NOVOS, the first-ever company to develop science-based solutions to slow down aging and increase human lifespan. Click HERE for part 1.

ENCORE: An Integrative Approach to Psoriasis and Psoriatic Arthritis, Part 1
August 21, 2024
Integrative rheumatologist Jill Weintraub MD explains how hi-tech medicines can be supported by lifestyle measures—including diet, stress reduction, and specific supplements. She’s the co-author of "Strategies to Treat Psoriasis and Psoriatic Arthritis: Everything You Wish Your Doctor Had Told You," where she offers comprehensive recovery plans with patient vignettes. She first details conventional options now available for autoimmunity, including the new biologic drugs. Dr. Weintraub discusses how diet can be deployed to reduce dependency on medications; the Mediterranean, Paleo, and vegan diets have been found helpful, as has intermittent fasting. Supplements like curcumin, omega 3s, and Boswellin may help tamp down inflammation; Adaptogens may counter the effects of stress; and probiotics and “gut-sealers” may address altered intestinal permeability. Androgens—especially DHEA—have proven helpful in lupus. A particular focus for Dr. Weintraub is patients who have signs of autoimmune susceptibility prior to formal diagnosis, who are ideal candidates for early intervention with natural modalities to forestall the development of full-blown disease. Click HERE for part 2.

ENCORE: An Integrative Approach to Psoriasis and Psoriatic Arthritis, Part 2

Dr. Hoffman continues his conversation with Dr. Jill Weintraub, author of "Strategies to Treat Psoriasis and Psoriatic Arthritis: Everything You Wish Your Doctor Had Told You." Click HERE for part 1.

Unlocking Longevity: The Power of Urolithin A, Part 1
July 31, 2024
Jen Scheinman, registered dietitian nutritionist and senior manager of nutrition affairs at Timeline Nutrition, delves into the unique benefits of the supplement Urolithin A, branded as Mitopure®, which supports mitochondrial function and may have widespread implications for longevity, muscle health, immune support, skin care, and potentially cancer recovery. The conversation covers the scientific research backing Urolithin A, its practical applications, and exciting new studies that could expand its uses. Real-world applications and user experiences are also shared, making this episode a comprehensive guide for anyone interested in enhancing their health through mitochondrial support. Right now Timeline is offering 10% off just for listening to Intelligent Medicine. Just click HERE and use code HOFFMAN at checkout. Click HERE for part 2.

Unlocking Longevity: The Power of Urolithin A, Part 2

Dr. Hoffman continues his conversation with Jen Scheinman, registered dietitian nutritionist and senior manager of nutrition affairs at Timeline Nutrition, a longevity company on a mission to improve healthspan. Click HERE for part 1.

Leyla Weighs In: Preventing Cognitive Decline
June 21, 2024
The Connection Between Community, Mobility, Exercise, and Cognitive Health. Nutritionist Leyla Muedin weighs in on the impact of community, mobility and exercise on cognitive function and overall health. She reviews recent studies, including one from the Journal of the American Geriatric Society, highlighting how greater community and mobility can be associated with better cognitive function, and another study from the journal Aging Cell that demonstrates exercise’s beneficial effects on brain health at the cellular level in mice. Additionally, Leyla discusses the harmful effects of air pollution on brain health and the importance of a holistic approach, emphasizing both physical activity and healthy lifestyle choices to mitigate cognitive decline and improve well-being.

Leyla Weighs In: Unveiling the Microbiome Theory of Aging (Second in a Series)
June 7, 2024
Nutritionist Leyla Muedin delves into the Microbiome Theory of Aging as outlined in Dr. Ross Pelton's article from the Integrative Medicine Clinician's Journal. The series explores the connection between gut health, dysbiosis, and aging, highlighting the role of dietary fibers and polyphenols in feeding probiotic bacteria to produce beneficial postbiotic metabolites. It also discusses zonulin's role in intestinal permeability, the negative impacts of the standard American diet on microbiome health, and the importance of a diverse plant-based diet for nurturing a healthy microbiome. Additionally, the episode critiques the efficacy of commercial probiotics versus the benefits of postbiotics and introduces postbiotic metabolites as an emerging, effective approach to improving gut health and overall wellness.

Leyla Weighs In: Unveiling the Microbiome Theory of Aging (First in a Series)
May 31, 2024
Nutritionist Leyla Muedin details the Microbiome Theory of Aging (MTA) through a comprehensive article by Ross Pelton in Integrative Medicine, a Clinician's Journal. The theory suggests that dysbiosis, or microbial imbalance in the gut, causes health problems that can accelerate biological aging by increasing inflammation, zonulin levels, intestinal permeability (leaky gut), and triggering chronic diseases. The episode covers the roles of probiotics, postbiotics, and how lifestyle factors influence the aging process. Leyla also discusses causes of dysbiosis, including diet, antibiotics, and stress, and introduces the concept of postbiotic metabolites as key regulators of health. The importance of the gut-brain axis and the effect of stress on microbiome dysfunction are also highlighted. The talk aims to provide insight into how maintaining a healthy gut microbiome can influence aging and health, setting the stage for a deeper dive in the next episode.

Mitochondria: The Energy Powerhouses of our Cells, Part 1
March 12, 2024
Today’s episode is a deep-dive on the mitochondria with a focus on the importance of free radical modification of cellular membranes. Membranes are the key to cellular aging. As we get older, the membranes in our cells accumulate damage caused by oxidative stress and other outside forces that result in the loss of mitochondrial function that can produce disease states, subjective fatigue, and have a direct bearing on aging. One of the nine pillars of aging is the deterioration of the mitochondria, the energy powerhouses of our cells. John Casey, co-founder and CEO of Nutritional Therapeutics, details how NTFactor® repairs membrane damage by replacing damaged, oxidized phospholipids with healthy, unoxidized phospholipids and returns cellular membranes to healthy function, reducing fatigue, repairing cellular damage, and reversing the effects of aging. Click HERE for part 2.