Investigative journalist Charles Piller reveals deep-seated corruption in Alzheimer’s research as chronicled in his book, “Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s Disease.” The discussion delves into the issues surrounding Big Pharma’s influence, fraudulent scientific studies, and the implications of a controversial 2006 experiment at the University of Minnesota. They also address the costly and marginally effective Alzheimer’s drugs like Aducanumab, the challenges faced by alternative research hypotheses, and the significance of improving scientific integrity and checks and balances in medical research.

Dr. Corey Schuler, PhD(c), FNP, DC, CNS, and director of medical affairs at Allergy Research Group, details his paper “Energy Allocation Resilience and Endocrine Integration” in the International Journal of Molecular Sciences. He introduces the Energy Allocation System (EAS), which emphasizes how the body allocates energy—not just produces it—and links many symptoms to impaired bioenergetics and resilience. They discuss mitochondria as energy generators and cellular signaling hubs, the integrated stress response and endocrine coordination (HPA axis, thyroid, gonads), and mitohormesis/eustress (exercise, fasting, heat/cold, circadian “zeitgebers”). Schuler explains nuanced testing for fatigue (diurnal cortisol, CGM patterns, thyroid markers including T3/reverse T3) and a case of a perimenopausal woman where oral contraceptives and cortisol dysregulation affected glucose patterns. They cover mitochondrial support (removing obstacles like pollutants/antibiotics, triglycerides, carnitine, dietary fats, micronutrients) and pacing/sequencing lifestyle interventions.

Q&A with Leyla, Part 1: Dr. Hoffman’s Scandinavian Trip

• Highlights from Dr. Hoffman’s Scandinavian trip
• Should I eliminate the nightshade family of foods from my diet?
• My friend has been experiencing acid reflux since using a reverse osmosis water filtration system

Q&A with Leyla, Part 2: Should we all be using unbleached toilet paper?

• Where can I access peptide therapy for my wife in California?
• What are other methods of lowering LDL doing exactly that niacin is not?
• Should we all be using unbleached toilet paper?
• Would I benefit from taking minoxidil and finasteride for hair growth?
• What can I do about my festoons?

Dr. Jacob Teitelbaum, an Integrative Medicine physician, researcher, and best-selling author specializing in chronic fatigue syndrome, details “adrenal fatigue,” contrasting Endocrine Society guidelines focused on overt adrenal failure with his view that the adrenals can be functionally exhausted and may be missed by standard testing and “normal ranges.” They discuss adrenal roles in stress response, blood sugar regulation, blood pressure, immunity, and symptoms suggesting low adrenal function (irritability when hungry, sugar cravings, fatigue, recurrent infections, lightheadedness/brain fog, mood shifts). Contributors include high sugar intake, chronic stress, dehydration, and salt restriction, with modern media fear/divisiveness cited as a major stressor; hypothalamic dysfunction and circadian rhythm disruption may cause “tired but wired” insomnia. They cover options such as licorice (not DGL), dietary and lifestyle changes, Adrenaplex, adaptogens (ashwagandha standards, HRG80 red ginseng study), phosphatidylserine for high nighttime cortisol, cautious low-dose hydrocortisone thresholds, and DHEA/pregnenolone considerations, plus resources at endfatigue.com.

Hyperbaric Oxygen Therapy (HBOT): Beyond the Bends—Wounds, Stroke Recovery, Radiation Injury, and Performance. Nicole Garrett, founder and COO of Under Pressure Hyperbarics, details hyperbaric oxygen therapy (HBOT). She explains how HBOT treats divers’ decompression sickness by recompressing nitrogen bubbles and reducing inflammation, and how therapeutic benefits depend on reaching adequate pressure (commonly around 2.0 atmospheres or more; diver treatment may begin at 2.8). Garrett describes HBOT’s history, FDA-approved uses such as diabetic wound healing, radiation injury, and sudden sensorineural hearing loss (often combined with steroids), and off-label use for stroke/TBI recovery, cognitive issues, autoimmune flares, Crohn’s disease, athletic recovery, anti-aging research (including telomere findings), and adjunctive cancer care. She contrasts “soft” chambers with higher-pressure medical chambers, discusses treatment courses (often 10–60 sessions), safety and contraindications (ears, pneumothorax, retinal bubble procedures), and practical barriers like cost, insurance coverage, and facility/oxygen regulations.

Intelligent Medicine Radio for May 16, Part 1: Hantavirus

Now do we have to start worrying about Hantavirus? Digestive enzymes for pancreatic insufficiency; Space exploration yields new treatments for resistant bacterial infections; Alternatives to prednisone for autoimmune hearing loss; Casey Means bows out of Surgeon General nomination—next up, Nicole Saphier; Multivitamins found to slow biological aging.

Intelligent Medicine Radio for May 16, Part 2: Hydrogen Water

Hydrogen water—breakthrough or scam? Osteoporosis fixes; Nattokinase for cardiovascular prevention; Why vitamin D helps a subset of diabetics; When oral vitamin D doesn’t work, sublingual D may normalize blood levels; Vitamin D found beneficial for colitis; Why fructose stokes food cravings; Flawed fluoridation study claims no IQ harms to kids.

Part 1: The Impact of Apple Cider Vinegar on Blood Sugar

• More on “eat the rainbow” . . . or not
• Medical breakthroughs that we don’t really need
• Can you discuss the order of eating macronutrients and its impact on blood glucose?
• What about the impact of apple cider vinegar on blood sugar?

Part 2: Does a plant based diet improve fertility?

• If I start taking urolithin A, will it make my insomnia worse?
• I’m a 54-year-old postmenopausal woman with no libido—can supplements help?
• Can you talk more about the vegan twin study, saying plant-based diet improved fertility?
• What do you think of IV NAD vitamin drips?

Sugarless: Dr. Nicole Avena on Hidden Sugars, Brain Addiction, and Practical Steps to Cut Back: Neuroscientist and author Dr. Nicole Avena reveals sugar’s pervasiveness and health impacts, drawing on her book “Sugarless: The Seven-Step Plan to Uncover Hidden Sugars, Curb Your Cravings, and Conquer Your Addiction.” Avena explains how modern industrialized, highly processed foods—many containing added sugars—have transformed innate preferences for sweetness into harmful overconsumption linked to obesity, diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and possible dementia via insulin signaling changes. She discusses research showing sugar can stimulate dopamine reward pathways similarly to drugs and that prenatal exposure may alter offspring metabolism, preferences, and sensitivity to drugs/alcohol. For solutions, she discourages strict “cold turkey” approaches due to hidden sugars and relapse psychology, emphasizes inventorying sources and triggers, starting with eliminating sugar-sweetened beverages and sugary coffee drinks, improving breakfast, choosing protein/fat-based snacks, and viewing alternative sweeteners as a temporary crutch; she also notes diet changes can improve mood stability and reduce anxiety.

Functional Diagnostic Nutrition: Using Saliva Testing, Food Sensitivity Labs, and Lifestyle to Find Root Causes: Reed Davis, Board Certified Holistic Health Practitioner (HHP) and Certified Nutritional Therapist (CNT), is founder of Functional Diagnostic Nutrition (FDN). He discusses using functional testing alongside conventional care to uncover “dysfunction” when standard labs appear normal. Davis describes assessing adrenal and metabolic stress via saliva testing for circadian cortisol patterns, cortisol-DHEA balance, sex hormones, secretory IgA, and melatonin, emphasizing clinical correlation and individualized “studies of one.” He outlines an approach targeting multiple “healing opportunities” (H-I-D-D-E-N: hormones, immune, digestion, detoxification, energy, nervous system) and applying D-R-E-S-S (diet, rest, exercise, stress reduction, supplementation) rather than relying on supplements alone. A case example links chronic hives, medication-related weight gain, and food triggers identified through additional testing, including the Mediator Release Test. The discussion also covers stress-driven gut dysbiosis, digestion decline, and EFT tapping for stress-related symptoms, and notes FDN practitioners can be found via FDNtraining.com/medicine.

Part 1: Cancer, Diabetes Risks from Food Preservatives

Press ballyhooed heart, stroke risks associated with Omega-3 supplementation, but new study dispels fears over fish oil-atrial fibrillation link; Research highlights cancer, diabetes risks from food preservatives; Do the new dietary guidelines go too far, or are they a cop-out? GLP-1 weight loss drug use could save airlines millions on fuel costs; Does a “complex tear” of the hip labrum inevitably require surgery?

Part 2: Can We Crack the Code on Aging?

Can we crack the code on aging, or are humans just “term-limited”? What are some of the most promising anti-aging interventions currently under investigation? We may be curing more cancers, and discovering them earlier, but certain cancers are increasing in incidence, especially among the young; Why extreme old age may be protective against cancer; Big meta-analysis confirms cardio benefits of low-carb diet; Patients with depression who’ve tried everything obtain surprising relief from vagus nerve stimulation; Blood sugar spikes after meals—even absent diabetes—can drive Alzheimer’s risk; New study pushes back on Tylenol-autism link, but highlights poor diet, chemical exposure , pre-natal anti-depressant use as potential culprits.