Jim LaValle, an internationally recognized clinical pharmacist, author, and lecturer, details the emerging field of peptide therapeutics. He discusses the basics of peptides, their roles in various bodily functions, and their therapeutic potentials, including weight loss, immune support, and injury recovery. Jim also shares insights on individualized dosage for GLP-1 drugs, regulatory challenges, the future of peptides in medicine, and exercise tips for seniors. Additionally, Dr. Hoffman explores Jim’s role in spearheading the MIORA Longevity Program at Lifetime Gyms, aiming to make gyms not just places for workouts but comprehensive wellness centers focused on longevity and health optimization.

Intelligent Medicine Radio for December 21, Part 1: 2024–A Year in Review

2024–a year in review (America’s worsening health picture); Obesity and cancer incidence rise in U.S. while healthspan declines; First-of-its-kind lawsuit takes aim at ultra-processed food makers; Nutritional support for childhood developmental disorders; Dr. Mark Hyman, integrative pioneer, gets the New York Times treatment; Can a blood pressure medication cause canker sores? Curbing Omega-6s, boosting Omega-3s, improves prostate cancer outcomes.

Intelligent Medicine Radio for December 21, Part 2: Wine is Good for Heart After All

New study says wine is good for heart after all—but should we drink more? How alcohol increases aggression by raising pain thresholds; Removing plastic chemicals can boost IQ, avert deaths, and save the world’s economy billions; Uterine thickening may be a prelude to endometrial cancer—can it be reversed? NIH study of green tea suggests it can; A new diagnosis of Sjögren’s syndrome has a caller spooked; Is the Internet making us dumber? Vitamin D in pregnancy gives kids stronger bones, but strikes out for diabetes prevention in healthy seniors; Dietary—but not supplemental—vitamin C curbs metabolic syndrome.

References and Resources

Research in 4 continents links outdoor air pollution to differences in children’s brains
Developmental Cognitive Neuroscience, Volume 69, October 2024, 101436

Obesity increases risk of mental disorders throughout life
Complexity Science Hub Vienna 05/30/23

How RFK Jr’s long time friend Mark Hyman built a wellness empire
By Brendan Borrell,  New York Times  12/18/24

A low omega-6, omega-3 rich diet and fish oil may slow prostate cancer growth
Journal of Clinical Oncology, 2024; DOI: 10.1200/JCO.24.00608

Dietary sources of vitamin C May lower risk for metabolic syndrome
Metabolic Syndrome and Related Disorders, Published Online: 28 October 2024

Cardiovascular protection tracks with wine intake, now provable with urinary marker
By Nicole Lou, PREDIMED trial. Medpage today  December 18, 2024

Science update: green tea compound may inhibit processes promoting uterine fibroid growth, NIH-funded study suggests
Scientific Reports. 2023. https://doi.org/10.1038/s41598-023-35212-6

Taking high-dose vitamin D supplements for five years did not affect the incidence of Type 2 diabetes
By JyrkinVirtanen,  Townsend Letter  December 13, 2024

Prenatal vitamin D supplementation increased bone density in children
The American Journal of Clinical Nutrition, 120(5), 1134–1142. doi:10.1016/j.ajcnut.2024.09.014.

Is the internet impairing your medical memory
By Nikhil Bhaskar, MSc, and Edward Feller, MD, Medpage Today  November 19, 2024

The benefits of removing toxic chemicals from plastics
PNAS 121 (52) e2412714121

‘I don’t feel your pain’: How alcohol increases aggression Study finds link to increase in pain threshold
Journal of Studies on Alcohol and Drugs, 2024; DOI: 10.15288/jsad.24-00144

Aphthous ulcer-a rare effect of losartan
Indian Journal of Pharmacy Practice, 2023; 16(2):163-165 

Q&A with Leyla, Part 1: Lifespan vs. Healthspan

• WHO Study on lifespan vs. healthspan in 183 countries
• Is there a danger in taking a supplement that enhances immunity if you have an autoimmune condition?
• I’ve had DCIS twice and feel I’ve received far too many mammograms. Can you discuss overtreatment?

Q&A with Leyla, Part 2: Overactive Bladder

• What does standardization in a supplement mean?
• Does the decaffeination process reduce beneficial polyphenols in coffees and teas?
• I’ve lowered my blood sugar but now my liver function tests are high. What gives?
• Is there a holistic treatment for hyperparathyroidism or is surgery the only option?
• What do you think of Gemtesa for overactive bladder?

In this episode of the Intelligent Medicine Podcast, Dr. Ronald Hoffman discusses the importance of hydration with Dr. Dana Cohen Integrative Medical Doctor and co-author of “Fuel Up: Harness the Power of Your Blender and ‘Cheat’ Your Way to Good Health.” They explore the often-overlooked role hydration plays in maintaining health and preventing chronic diseases. Dr. Cohen emphasizes practical strategies to improve hydration through diet and lifestyle changes. They highlight the risks of both dehydration and overhydration, discuss the impact of processed foods, and offer realistic solutions to help listeners incorporate better hydration practices into their lives. Too often doctors are dismissive of pop culture exhortations to pay attention to hydration. Except for those with specific medical conditions, the conventional mantra remains “In ordinary healthy individuals, thirst is a good guide to how much fluid you should consume.” In medicine, we routinely query patients about their diets, their exercise, their sleep, their stress levels, drug, alcohol and tobacco use, their social interactions, their spirituality, even their sexuality. But so seldom do we ask “How’s your hydration?” A recent review found that “Hypohydration is known to reduce mental and physical performance, and more recent evidence suggests hypohydration also impairs vascular function and cardiovascular regulation.” But adequate fluid intake is not merely a matter of optimization; a recent medical study sampling 1200 adults aged 51-70  suggests that it may literally be a matter of life and death: “. . . underhydration was significantly associated with increased prevalence of obesity, high waist circumference, insulin resistance, diabetes, low HDL, hypertension, and metabolic syndrome. Over 3–6 years of follow-up, 33 chronic disease deaths occurred in the sample, representing an estimated 1,084,144 deaths in the U.S. Alongside chronic health conditions, underhydration was a risk factor for an estimated 863,305 deaths. Independent of the chronic health conditions evaluated, underhydration was a risk factor for 128,107 deaths.” How prevalent is underhydration in a sample of American adults? According to the study: “Nationally representative data from the National Health and Nutrition Examination Survey (NHANES) indicate that over 65% of adults aged 51–70 years in the U.S. do not meet hydration criteria.” The episode also touches upon broader health issues, contrasting dietary extremes, and the importance of accessible, enjoyable healthy eating habits.

Dr. Michael Karlfeldt offers a deep dive into integrative oncology and the importance of immune support, especially during the winter season. He delves deep into the immune-protective benefits of fermented wheat germ extract and AHCC, which combine in ImmPower PLUS to offer comprehensive immune enhancement, cancer prevention, and treatment support. The discussion highlights the role of natural killer cell activity, the Warburg effect, and the adaptogenic properties of these supplements in addressing both cancer and general immune health. Practical dosing recommendations and Dr. Karlfeldt’s insights into the integration of conventional and alternative therapies provide valuable knowledge on how to bolster immune systems effectively. Use coupon code HOFFMAN10 at checkout to get a 10% discount and free shipping.

Intelligent Medicine Radio for December 14, Part 1: Parasites

Borrowing from tobacco industry litigation, law firm launches major suit against ultra-processed food conglomerates; Big Food employs same tactics as cigarette makers once did to delegitimize, intimidate critics; Are parasites the hidden culprit in cancer? Beers contain detectable levels of pesticides—as new evidence links glyphosate to neurodegenerative diseases; For some breast cancers, weight loss drugs may interfere with chemo efficacy; How to lower C-reactive protein? Ultra-processed foods contribute to psoriasis severity. 

Intelligent Medicine Radio for December 14, Part 2: Best Diet for Prostate Cancer

When hemoglobin A1c is inconsistent with fingerstick glucoses; A landmark study demonstrates improved muscle strength with urolithin A; Healthy diet can tamp down chronic pain; A mysterious new toxic compound detected in chlorinated water supplies; Long-term antibiotic use hikes risk for rheumatoid arthritis; Omega-3 scores vs. heart failure; Vegetarians consume more processed foods than those who consume meat; Best diet for prostate cancer. 

References & Resources

Exclusive warning as experts discover weight loss jabs like Ozempic render breast cancer chemo ineffective
By Emily Stearn, DailyMail.com  December 12, 2024

Ultra-processed foods implicated in psoriasis activity
JAMA Dermatology. doi:10.1001/jamadermatol.2024.4832

Study reveals lasting effects of common herbicide on brain health
Journal of Neuroinflammation, 2024; 21 (1) DOI: 10.1186/s12974-024-03290-6

Beer weed killer score
robertlufkinmd.com

New study reveals intimidation tactics against researchers by tobacco, ultra-processed food and alcohol sectors
Health Promotion International, Volume 39, Issue 6, December 2024, daae153

Morgan&Morgan files lawsuit over allegedly harmful, addictive ultra-processed food
Morgan & Morgan America’s Largest Injury Law Firm

Some ultra-processed foods are as addictive as cigarettes and cocaine
By Mikaela Conley, usrtk.org  Feb 28, 2024

Vegetarians consume more ultra-processed foods than those who regularly eat meat
By Bob Yirka, Medical Xpress  November 27, 2024

Study shows omega-3 protects against heart failure
Mayo Clinic Proceedings Volume 99, Issue 12p1857-1859December 2024

A healthy diet helps the weight battle with chronic pain
University of South Australia,  December 9, 2024

Long-term antibiotic use may elevate risk for rheumatoid arthritis
by Mary Stroka  Rheumatology Advisor  December 4, 2024

Scientists identify previously unknown compound in drinking water
Science, 2024; 386 (6724): 882 DOI: 10.1126/science.adk6749

Urolithin A’s benefits for muscle strength and endurance get RCT boost
Journal of the International Society of Sports Nutrition, 21(1). https://doi.org/10.1080/15502783.2024.2419388

Q&A with Leyla, Part 1: Copper Supplements

• WSJ: Trump nominees ‘hawking’ supplements?
• Correction on Surgeon General Nominee Dr. Janette Nesheiwat’s husband
• I have chronic fatigue. Do you think I would benefit from taking a copper supplement?
• Can I take garlic pills to help my eosinophilic esophagitis?

Q&A with Leyla, Part 2: Post Nasal Drip

• I’ve been taking Nexium for the last 20 years. Is this contributing to lower bone mineral density?
• Should my 83-year-old wife take more calcium for her osteopenia?
• What is your knowledge of Prolia? What are the side effects?
• I have mitral annular disjunction (MAD). Can you advise me?
• What can I take for my post nasal drip?
• Are there other blood thinners I can take where I don’t need to check my INR?

Lex Pelger, a biochemist and educator in cannabinoid science, details unique non-CBD supplements from CV Sciences that have similar beneficial effects on the endocannabinoid system as CBD. The discussion includes the benefits of CBD and cannabinoids, the new +PlusHLTH line (including Peace Gummies, Clarity Gummies, and Reshape Capsules), and their ingredients like berberine, cinnamon, and OEA for metabolic health. They also touch on regulatory challenges and the potential future of cannabis, CBD, and psychedelic research under varying political climates.

The Impact of Refrigeration on Food, Health, and the Planet: Nicola Twilley, author of “Frostbite: How Refrigeration Changed Our Food, Our Planet, and Ourselves,” details the historical development of refrigeration, its profound impact on food preservation, diets, and urbanization. The conversation also covers the technological and environmental challenges posed by refrigeration, alternative food preservation methods, and the consequences for small farmers and the global food system. Nicola also shares insights into the health implications of refrigeration and the innovative solutions being explored to reduce its environmental footprint.

Intelligent Medicine Radio for December 7, Part 1: The Tiredest Generation

A healthcare company COO is gunned down—and there could be millions of suspects with a grievance; A simple maneuver can alleviate vertigo; Olive polyphenol found to aid mitochondrial respiration; Gen Z is tiredest generation; Did sickle trait contribute to the death of subway of Jordan Neely? Is screening for sickle trait in athletes a form of discrimination? Daily chores can help women avert cardiovascular events. 

Intelligent Medicine Radio for December 7, Part 2: Cholesterol Lowering Guidelines

How appropriate are cholesterol-lowering guidelines? Are Americans really ready for bans on colorful synthetic food dyes? New powerful drugs promise to slash LDL cholesterol—but are they overused? How to stay fit when arthritis limits exercise; The genetics of acute myeloid leukemia; Cattle feed Bovaer promises to curb methane emissions—but critics claim it’s toxic; Carrageenan may prompt insulin resistance, systemic inflammation; Should you really toss that black plastic spatula?

References and Resources

Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance
Cell Metabolism Available online 26 November 2024

Gen Z are tired
By Lucy Notarantonio, Newsweek  November 26, 2024

Super Bowl champ Ryan Clark offers own perspective on Damar Hamlin: ‘At 24, I didn’t even know I could die’
By Ryab Gaydos, Fox News Jan 3, 2023

Blood doctors call foul on NCAA’s screening for sickle cell
By Scott Hensley, NPR  January 12, 2012

NCAA’s sickle cell screening hints at discrimination
By Yun Xie, aaas.org  November 2, 2010

Daily chores may provide cardiovascular protection in women who don’t exercise
By Nicole Lou, Medpage Today  December 3, 2024

United Healthcare’s disturbing track record of rejecting claims as CEO Brian Thompson is shot dead in New York
By Laura Parnaby, Daily Mail.com  December 4, 2024

Expert reaction to social media posts about cattle feed additive Bovaer
Science Media Centre  December 3, 2024

Evidence is growing that microbes in your mouth contribute to cancer
By Linda Geddes, New Science November 18, 2024

New cholesterol guidelines could drastically reduce statin use for millions
JAMA Intern Med. 2024;184(8):963–970. doi:10.1001/jamainternmed.2024.1302

Carrageenan and insulin resistance in humans: a randomized double-blind cross-over trial
BMC Med 22, 558 (2024). https://doi.org/10.1186/s12916-024-03771-8

Yes, you really should toss that black plastic spatula
By Samantha Reddy, WSJ  November 27, 2024

Silly Rabbit! Original Trix with artificial colors is back after customers revolt
By Annie Gasparro, WSJ  September 21, 2017

What is the best-selling cereal in the United States?
https://www.kulicksfrenchtoastrecipes.com/the-19-most-popular-cereals-based-on-boxes-sold/
Kulicks French Toast Recipes | Learn How To Make The BEST French Toast

We battled Big Food. Can RFK, Jr succeed where we failed?
By Thomas Farley and Tom Friedan, WSJ Novermber 29, 2024