Nathan Jones, CEO of Xlear, Inc., details the benefits of xylitol in dental and respiratory health products such as nasal sprays and chewing gums under the Spry brand. Nathan advocates for the FDA to allow anti-cavity claims for xylitol and other compounds despite the current monopoly of fluoride in such claims. They question the efficacy and potential downsides of fluoride, and explore alternative dental health interventions. The episode also covers xylitol’s role in preventing tooth decay, respiratory health benefits during the COVID-19 pandemic, and ongoing legal challenges with the FTC. Discussions highlight the potential implications of oral health on systemic diseases like cardiovascular disease and Parkinson’s, and emphasize the importance of nasal hygiene alongside dental care.

Part 1: Benefits of Cocoa Flavanols

“Study” that’s not even a study spreads panic about dubious melatonin-heart failure link; Should you ignore Dr’s advice to take powerful acid-blocking drugs? Novel implantable electrical pacemakers may bring relief to sufferers of severe constipation; Benefits of cocoa flavanols for heart, brain, athletic performance. 

Part 2: Coffee and Atrial Fibrillation

The FDA belatedly liberates women’s hormone replacement; Beta-blockers now deemed passé for routine heart attack aftercare; After most breast cancer surgery, adjuvant radiation brings no survival benefits; Can you drink caffeinated coffee if you have atrial fibrillation? Ignore frequent falls without attention to balance and stability training at your peril; Is it reasonable to contemplate a knee replacement surgery at 88? 

References & Resources

Melatonin as a novel drug to improve cardiac function and quality of kid in heart failure patients: a systematic review and meta-analysis.
Clinical Cardiology. 2025 Mar;48(3):e70107. doi: 10.1002/clc.70107.

A study questions melatonin use and heart health, but lose sleep over it
By Lauren Neergaard, Associated Press  November 7,2025

Burst-patterned stimulation restores colonic motility in preclinical models
Sci Transl Med. 2025 Nov 5;17(823):eadu4615. doi: 10.1126/scitranslmed.adu4615. Epub 2025 Nov 5. PMID: 41191773.

Speaking multiple languages may slow down biological aging
Nat Aging 5, 2340–2354 (2025). https://doi.org/10.1038/s43587-025-01000-2

Cup of coffee a day may not be harmful for some adults with AFib and could lower episodes
American Heart Association Scientific Sessions 2025 Late-Breaking Science Abstract 4377429

RADIATION may be unnecessary for many breast cancer patients
N Engl J Med 2025;393:1771-1783

Beta blockers have no effect on heart attack patients
N Engl J Med 2025 Aug 30 Ibanez B et al. N Engl J Med 2025 Aug 30

Marty Makary: The FDA liberates women’s hormone replacement therapy
By Marty Makary. WSJ  November 10, 2025

Q&A with Leyla, Part 1: Are children’s IQs going down?

• Are children’s IQs going down?
• An overview of medical reversals
• Can you comment on the melatonin and heart failure study?
• Result of a prostate artery embolization

Q&A with Leyla, Part 2: The State of our Healthcare System

• I have hypothyroidism.  Do I need to be concerned about low ferritin levels?
• What are the benefits of lower-dose fish oil?
• Is there a connection between melatonin supplementation and depression?
• Can I take melatonin while on warfarin?
• What to do about the state of our healthcare system?

Fertility specialist Gabriela Rosa, the CEO and founder of the Rosa Institute, discusses the decline in fertility rates, the experiences of couples struggling to conceive, and the multifaceted methods used to address this issue. Gabriela shares her journey of merging conventional and holistic fertility sciences, citing real-life cases of couples who succeeded in conceiving after addressing underlying health issues. They delve into the importance of lifestyle factors, such as diet, exercise, and mental health, and discuss specific interventions like hormone management and supplements. The conversation also covers environmental influences, the role of metabolic health, and the critical importance of personalized treatment plans for couples facing infertility. Gabriela provides insights on how to balance high-tech and holistic approaches to optimize fertility outcomes.

Neil Levin, Senior Nutrition Education Manager and product formulator for Now Foods and Protocol for Life Balance, discusses the importance of targeted nutrients for women’s health. They delve into various supplements such as magnesium, myo-inositol, progesterone cream, D-Mannose, and biotin, explaining their benefits for conditions like PCOS, blood sugar regulation, menstrual migraines, urinary tract infections, and overall skin, hair, and nail health. The conversation also touches on the importance of tailoring nutrients to individual needs and the role of personalized nutrition in supporting women’s health amidst modern stresses.

Part 1: 4 Simple Lifestyle Measures Deliver 9 Additional Years of Disease-Free Healthspan

Just 4 simple lifestyle measures deliver 9 additional years of disease-free healthspan; Study underscores protein’s role in staving off cancer, heart disease, and death; CoQ10 scores vs. neurodegeneration; Urolithin A (Mitopure®️) found to support athletic performance, immune function; Why you should ignore some influencers’ advice to avoid fish oil. 

Part 2: New Non-Invasive Option for Men’s Age-Related Urinary Problems

As little as 3000 steps per day can slow progression to Alzheimer’s Disease; Self-reports of memory impairment soaring among young people; New study vindicates unprocessed red meat—and even often-vilified processed red meat—for cancer and overall health. Prostate artery embolization (PAE) offers new non-invasive option for men’s age-related urinary problems; Targeting the mitochondria and the microbiome for Parkinson’s Disease; Popular prostate and hair loss prevention drugs linked to depression and suicide—while Cialis for urinary symptoms may stave off cardiovascular disease; Discovery that a safe, cheap medication may increase survival after breast cancer surgery. 

References & Resources

Coenzyme Q10 attenuates age-associated neurodegeneration via modulation of autophagy and neuroinflammation in aged rats
Metab Brain Dis. 2025 Nov 3;40(8):305. doi: 10.1007/s11011-025-01721-8.

Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
Nat Aging. 2025 Nov;5(11):2309-2322.

Dietary intake of total, animal, and plant proteins and risk for all-cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies
BMJ 2020;370:m2412

Association of healthy lifestyle with years lived without major chronic diseases
JAMA Intern Med. 2020;180(5):760–768. doi:10.1001/jamainternmed.2020.0618

Unprocessed red meat and processed meat consumption: dietary guidelines recommendations from the Nutritional Recommendations (NutriRECS) Consortium
Annals of Internal Medicine Volume 171, Number 10

Long-term effects of phosphodiesterae-5 inhibitors on cardiovascular outcomes and death:a systematic review and meta-analysis
Eur Heart J Cardiovasc Pharmacothe. 2024 Aug 14;10(5):403-412.

Popular hair-loss pill linked to depression and suicide
J Clin Psychiatry 2025;86(4):25nr15862

Oral bacteria may trigger Parkinson’s Disease
Neuroscience News, September 22, 2025

Scientists just shattered a major exercise myth
Advances, 2025; 4 (10): 102140 DOI: 10.1016/j.jacadv.2025.102140

Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease
Nature Medicine Published: 03 November 2025

Alarming surge in memory problems among young adults
Neurology, 2025; 105 (8) DOI: 10.1212/WNL.0000000000214226

Q&A with Leyla, Part 1: Melatonin for Bone Mineral Density?

• More on gadolinium effects and detox
• I was found to have a small pericardial effusion. What advice can you give me?
• Is melatonin beneficial for bone mineral density? If so, how much should I take?

Q&A with Leyla, Part 2: Coffee Enemas for Liver Detox?

• Study: Mitopure’s impact on immune parameters
• What important blood tests should one get, and what are the ideal levels to look for?
• I do coffee enemas for liver detox. How many can I do per week?  
• I’ve been on Metformin and lost some weight. Should I increase my dose to lose more?
• Could a recent dental implant be causing clogged ears and a hissing noise?

Marina Pavlovic Rivas, co-founder and CEO of Eli Health, reveals a revolution in personal health monitoring through advanced wearable devices. They discuss the journey from primitive step counters to sophisticated devices, such as continuous glucose monitors (CGMs) and the world’s first instant hormone monitoring system by Eli Health. The conversation delves into the new cortisol testing kit from Eli Health, exploring its implications for understanding stress, sleep, metabolism, and overall health. Rivas explains the process of using the device, its integration with a smartphone, and how AI helps interpret the hormone data for actionable insights. Future plans for Eli Health’s hormone monitoring technology, including progesterone and testosterone, are also discussed, offering a glimpse into the evolving landscape of self-monitoring and personalized health.

Dr. Alan Rozanski, a distinguished Professor of Medicine at the Icahn School of Medicine at Mount Sinai and Director of Nuclear Cardiology at Mount Sinai St. Luke’s in New York City, details the holistic aspects of medicine, emphasizing the integrative approach involving lifestyle, mental health, exercise, and the psychological dimensions of heart health. Dr. Rozanski reveals the six domains of optimal health and vitality, sharing insights from his pioneering work in integrating such approaches into cardiology, the significant impact of stress, and the importance of maintaining a sense of life purpose and social connections. He also delves into modern imaging techniques, the utility of coronary artery calcium scores, and emerging treatments like GLP-1 drugs for cardiovascular health. The conversation provides a thorough exploration of comprehensive health management strategies beyond just medication and surgery.

References & Resources

Mechanisms and clinical applications of Palmitoylethanolamide PRA in the treatment of neuropathic pain
Inflammopharmacology. 2025 Jan;33(1):121-133. doi: 10.1007/s10787-024-01623-8. Epub 2024 Dec 23. PMID: 39714723.

It’s not just about hitting daily step counts
By Joedy McCreary, Medpage Today, October 21, 2025

Daylight saving time may not trigger heart attacks after all
JAMA Netw Open Published Online: September 9, 2025;8;(9):e2530442.

Vitamin D and Marin omega-3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial
BMJ 2022;376:e066452

Omega-3 benefits may vanish quickly after you stop
JCI Insight, 2025; 10 (19) DOI: 10.1172/jci.insight.193637

Does early life exposure to antibiotics increase the risk of eczema?
Br J Dermatol. 2013 Nov;169(5):983-91. doi: 10.1111/bjd.12476. PMID: 23782060.

Improvement of skin lesions in corticosteroid withdrawal-associated severe eczema by multi-component traditional Chinese medicine therapy
Allergy Asthma Clin Immunol 17, 68 (2021). https://doi.org/10.1186/s13223-021-00555-0

Bronx woman beaten to death by hospital roommate
By Mira Wassef, Anthony DiLorenza, Pix11, October 8, 2025

Cold water for cleaner hands?
By Andrew WeilMD, April 10, 2014

Exposure to sugar rationing in first 1000 days after conception and long term cardiovascular outcomes:natural experiment study
BMJ 2025;391:e083890

Comparing very low carbohydrate vs DASH diets for overweight or obese adults with hypertension and prediabetes or type 2 diabetes: a randomized trial
The Annals of Family Medicine May 2023, 21 (3) 256-263; DOI: https://doi.org/10.1370/afm.2968

Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
The American Journal of Clinical Nutrition Volume 122, Issue 1, July 2025, Pages 39-47

Vitamin D protects against depression: Evidence from an umbrella meta-analysis on interventional and observational meta-analyses direct
Pharmacological Research Volume 187, January 2023, 106605

Doctor tripped up by $64K bill for ankle surgery and hospital stay
By Julie Appleby, KFF Health News  October 29, 2025

Part 1: Topical Steroid Withdrawal

TSW—Topical Steroid Withdrawal—when you’re hooked on steroid creams for a skin condition and can’t get off; Can diet, supplements, or Traditional Chinese Medicine help eczema? Strange bedfellows—when your hospital assigns you a homicidal roommate; Every step you take may reduce your risk of dying; Vitamin D and Omega-3 supplements reduce risk of autoimmune conditions; How long to curtail fish oil before a medical procedure or surgery? Supplements for neuropathy.

Part 2: Daylight Savings Time Changeover Health Myths

Daylight Savings Time changeover health myths busted; A doctor breaks her ankle and is billed $64,000 in uncovered expenses; Vitamin D shields life-prolonging telomeres, may help depression; The vaunted DASH Diet for hypertension faces off against low-carb alternative; The critical first 1000 days after conception—early life sugar avoidance yields major later life health dividends; Do you really need hot water to disinfect your hands?

References & Resources

Mechanisms and clinical applications of Palmitoylethanolamide PRA in the treatment of neuropathic pain
Inflammopharmacology. 2025 Jan;33(1):121-133. doi: 10.1007/s10787-024-01623-8. Epub 2024 Dec 23. PMID: 39714723.

It’s not just about hitting daily step counts
By Joedy McCreary, Medpage Today, October 21, 2025

Daylight saving time may not trigger heart attacks after all
JAMA Netw Open Published Online: September 9, 2025;8;(9):e2530442.

Vitamin D and Marin omega-3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial
BMJ 2022;376:e066452

Omega-3 benefits may vanish quickly after you stop
JCI Insight, 2025; 10 (19) DOI: 10.1172/jci.insight.193637

Does early life exposure to antibiotics increase the risk of eczema?
Br J Dermatol. 2013 Nov;169(5):983-91. doi: 10.1111/bjd.12476. PMID: 23782060.

Improvement of skin lesions in corticosteroid withdrawal-associated severe eczema by multi-component traditional Chinese medicine therapy
Allergy Asthma Clin Immunol 17, 68 (2021). https://doi.org/10.1186/s13223-021-00555-0

Bronx woman beaten to death by hospital roommate
By Mira Wassef, Anthony DiLorenza, Pix11, October 8, 2025

Cold water for cleaner hands?
By Andrew WeilMD, April 10, 2014

Exposure to sugar rationing in first 1000 days after conception and long term cardiovascular outcomes:natural experiment study
BMJ 2025;391:e083890

Comparing very low carbohydrate vs DASH diets for overweight or obese adults with hypertension and prediabetes or type 2 diabetes: a randomized trial
The Annals of Family Medicine May 2023, 21 (3) 256-263; DOI: https://doi.org/10.1370/afm.2968

Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
The American Journal of Clinical Nutrition Volume 122, Issue 1, July 2025, Pages 39-47

Vitamin D protects against depression: Evidence from an umbrella meta-analysis on interventional and observational meta-analyses direct
Pharmacological Research Volume 187, January 2023, 106605

Doctor tripped up by $64K bill for ankle surgery and hospital stay
By Julie Appleby, KFF Health News  October 29, 2025