Q&A with Leyla, Part 1: A Tragic Case of Rhabdomyolysis at the NYC Marathon

• A tragic case of rhabdomyolysis at the NYC Marathon.
• What advice do you have for getting off antidepressant medication?
• What are some ways I can prevent cognitive decline?

Q&A with Leyla, Part 2: Botox and Other Fillers

• Studies – remission of type 2 diabetes and reversal of fatty liver
• How long do I have to nurse my hamstring injury?
• I’ve had diarrhea for three weeks now. Should I see a doctor?
• What are your thoughts on Botox and various other fillers? Any dangers?

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman hosts Dr. James Kimmel, a lecturer in psychiatry at the Yale School of Medicine, to discuss the psychology and science behind revenge. Dr. Kimmel explains how revenge operates similarly to an addiction in the brain, triggering the same pleasure and reward circuits. He recounts his own traumatic experience with bullying and how it led him to understand the destructive nature of revenge. The discussion covers the implications for criminal justice, the role of social media in exacerbating revenge behaviors, and practical strategies for managing revenge cravings, including the potential benefits of forgiveness. Dr. Kimmel’s new book, “The Science of Revenge,” explores these themes and offers insights into breaking free from the cycle of retribution.

Dr. Ronald Hoffman interviews King’s College London epidemiologist and ZOE co-founder Prof. Tim Spector about his book, “Ferment,” and the science of fermented foods. Spector describes his shift from genetics and twin studies to microbiome research after finding identical twins had very different gut microbes. He outlines key drivers of Western microbiome loss—antibiotics, pollution/pesticides, sterile urban living, smaller families, and especially low-fiber, ultra-processed diets with additives. They discuss COVID-era findings linking diet quality to outcomes, and clinical and population evidence that fermented foods can reduce inflammatory markers and quickly improve mood, energy, hunger, bloating, and modest weight. Spector explains mechanisms involving immune effects in the small intestine, plus postbiotics. He critiques artificial sweeteners and processed “analog” cheeses, contrasts benefits of real and raw-milk cheeses, notes coffee/chocolate as fermented, and highlights future precision nutrition, prebiotics, and microbiome impacts on cancer immunotherapy.

Part 1: Depression and Circadian Rhythm Disruptions

Bone density can be IMPROVED with the right combination of resistance and high-impact exercises; Why bone preservation matters when it comes to healthspan, longevity; Would BWH 85 Beta Glucan fend off multiple myeloma? Hard-to-treat depression may stem from circadian rhythm disruptions; Personalized mRNA cancer vaccines: Cancer breakthrough or pricey dead-end? Why Moderna stock is so volatile; Creatine plus resistance exercise fends off menopause woes.

Part 2: The “10,000 Step Rule”

The arbitrariness of the “10,000 step rule”; Forest-bathing delivers more brain and body benefits than ordinary walking; How does BWH Beta Glucan compare to AHCC? Why ApoB might yield better heart risk prediction than just LDL and HDL; Can vitamin C and glutathione be given together intravenously? When your fingertips turn white and blue in the cold; Exercise improves sleep—but so, too, does a healthy microbiome.

Q&A with Leyla, Part 1: Chronic Insomnia

• Exercise training for bone health
• Why has my Lipoprotein (a) trended upward in the last 4-5 years? Isn’t it genetically determined?
• I have chronic insomnia, and my doctor told me to avoid any supplements due to my pacemaker/defibrillator

Q&A with Leyla, Part 2: Total Knee Replacement

• My husband is getting a total knee replacement. What do you recommend as far as food and supplements for recovery?
• Can I safely use Xlear nasal spray after getting a stent in one of my arteries?
• If a person has GERD occasionally, would it be advisable to avoid meat since it is acid-forming?
• I have a family history of rheumatoid arthritis. How can I prevent this?  

Why Brains Need Friends: The Neuroscience of Loneliness, Empathy, and Social Connection. Dr. Ronald Hoffman interviews neuroscientist Dr. Ben Rein about his book, “Why Brains Need Friends,” focusing on how loneliness and social isolation affect well-being and health. Rein describes his research on the neurobiology of autism, empathy, and how MDMA enhances empathy via serotonin signaling in the nucleus accumbens, and argues that humans are evolutionarily wired for social reward through oxytocin, serotonin, and dopamine. They distinguish objective isolation from subjective loneliness and discuss how isolation can trigger chronic stress responses, elevated cortisol, inflammation, and increased risks including stroke, dementia, heart disease, depression, anxiety, and suicide. Rein explains why digital communication (text, phone, Zoom) is less fulfilling due to reduced social cues and can erode empathy online; offers practical strategies to “level up” interactions from shallow to deep, track one’s social cadence based on introversion/extroversion, and addresses pets, social anxiety treatment, alcohol as a social lubricant, and concerns about robot companions.

Exercise as Medicine for Osteoporosis: Dr. Ronald Hoffman interviews Professor Belinda Beck of Griffith University, a director of The Bone Clinic, and co-founder of ONERO, an award-winning, evidence-based exercise program for osteoporosis. Beck explains bone as living tissue that remodels in response to mechanical loading (Wolff’s Law), arguing much age-related loss reflects insufficient stress and that targeted high-load training can rebuild bone. She contrasts exercise with calcium-only approaches, noting supplementation limits and potential cardiovascular risks, and reviews osteoporosis drugs (bisphosphonates, denosumab/Prolia, PTH analogs, romosozumab/Evenity), including rebound loss after stopping denosumab and microdamage repair issues with antiresorptives; medications don’t prevent falls. Beck describes her “LIFTMOR” trial: twice-weekly, 30-minute supervised high-intensity resistance and impact training for eight months improved spine BMD, produced hip structural strengthening, and improved functional fall-risk measures versus low-intensity controls. ONERO is a standardized, supervised program delivered by trained clinicians, can be additive with medication or hormone therapy, and locations can be found via the ONERO Academy website.

More Resources:

• The ONERO® Summit website (an educational meeting for ONERO® licensees, doctors and patients/the public)
• The Bone Clinic Facebook page (for information and important advances in the field of bone health in lay terms)

Part 1: Can eye drops dissolve cataracts?

A quick, 4-minute daily exercise fix for over-65s boosts performance in just 12 weeks; can eye drops dissolve cataracts to forestall surgery? A new motion sickness drug is named after the Greek god who was sailors’ friend; Scientific American highlights mitochondria as key to healthy aging; Urolithin A notches gains for GI and heart health in new studies.

Part 2: Which diet scored highest for staving off biological aging?

The biggest mistake GLP-1 weight loss medication users make; Scientists discover link between vitamin C and blood cancers; B12 alone, or taken with a B complex? 10 diets are put to the test, and which scored highest for staving off biological aging? When medications cause constipation; Overcoming fatigue after radiation treatment for cancer.

Q&A with Leyla, Part 1: Helpful Nutrition for Cancer

• Pope Leo’s cancer diagnosis and treatment
• Helpful nutrition for cancer
• My LDL cholesterol is higher now, but my calcium score is “0”.  Should I be concerned?

Q&A with Leyla, Part 2: Spinal Stenosis

• My husband’s homocysteine went up to 15, and he already takes Methyl Action.  What else can he take to lower it?
• I had candida in the past.  Is it okay for me to take a supplement that contains baker’s yeast?
• Is there anything I can do to alleviate spinal stenosis?
• What kind of creatine supplement should I take, and how much to regain muscle strength?

Henry Abbott, former ESPN journalist, basketball expert, and author of the highly anticipated book “Ballistic: The New Science of Injury-Free Athletic Performance,” details how advanced biomechanical analysis can help prevent athletic injuries. Abbott explains the significance of movement patterns, particularly how techniques used by elite athletes at the Peak Performance Project (P3) in Santa Barbara can be applied to everyday people. The conversation covers various topics, including plyometrics, the importance of hip stability and mobility, and the potential for new technologies like AI and computer vision to bring these advanced assessments and training techniques to a wider audience. The episode is rich in practical advice for maintaining physical health and mobility through a lifelong commitment to better movement practices.